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高温对SARS-CoV-2生存能力的影响
Harapan Harapan1,2,3, Edison Johar4, Chairin Nisa Maroef4
1Department of Microbiology, School of Medicine, Universitas Syiah Kuala, Banda Aceh, 23111, Indonesia.
F1000Research
|September 25, 2023
概括
将温度提高到40°C显著降低了SARS-CoV-2的生存能力,而55°C则消除了它. 这一发现支持将热用于患者热疗和隔离室灭菌,以对抗COVID-19.
科学领域:
- 病毒学 病毒学
- 传染性疾病 传染性疾病
- 生物医学工程 生物医学工程
背景情况:
- 严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 对医疗保健工作者构成重大风险.
- 开发有效的隔离室对于减少患者治疗期间的病毒传播至关重要.
- 了解病毒通过温度等环境因素的无活化是设计更好的制策略的关键.
研究的目的:
- 为了评估高温降低SARS-CoV-2生存能力的有效性.
- 收集数据以优化COVID-19患者隔离室的设计.
- 探索轻度高温症作为治疗方法的潜力.
主要方法:
- 化SARS-CoV-2 (印尼分离物) 在25°C至65°C的温度下,持续一个小时.
- 在Vero E6细胞上使用斑块检测对病毒活性的评估.
- 在不同温度点和室温控制下比较病毒标位.
主要成果:
- 在40°C观察到SARS-CoV-2活力的显著降低 (从10^13 PFU/mL到10^9 PFU/mL).
- 55°C及以上的温度完全消除了病毒的生存能力.
- 该研究表明,温度升高和病毒失活之间存在明显的剂量依赖关系.
结论:
- 高温,特别是55°C,可以有效地消毒隔离室.
- 轻度高温 (大约40°C) 可能通过减少病毒载量为COVID-19患者提供治疗效益.
- 温度控制是开发优化隔离室的关键因素,用于管理SARS-CoV-2感染.
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