一个3岁的女孩的抗SOX1抗体,病毒后
Aline Wijnand1, Helene Verhelst2
1Department of Child and Adolescent Psychiatry, Ghent University Hospital, Ghent, Belgium.
Child neurology open
|September 25, 2023
概括
这份病例报告详细介绍了一例罕见的在小孩中出现抗SOX1抗体,后者感染了水. 它强调了这些神经元上自身抗体的新临床关联.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 儿科 儿科 儿科
背景情况:
- 与抗SRY相关的HMG-box基因1 (SOX1) 抗体与成年人的神经神经障碍有关.
- 患有抗SOX1抗体的儿童病例很少见,以前仅有两例报告.
- 脑神经自抗体是诊断神经疾病的关键生物标志物.
研究的目的:
- 报告一个小孩子抗SOX1抗体的独特病例.
- 描述临床表现和诊断发现.
- 为了研究抗SOX1抗体与疹后感染之间的关联.
主要方法:
- 临床病例介绍和详细的病史.
- 对抗SOX1抗体进行血清和脑脊液 (CSF) 检测.
- 综合性瘤查和随访.
主要成果:
- 一个3岁的女孩出现了,失衡,尿失禁,以及疹感染后的行为变化.
- 在血清和脑脊液中检测到抗SOX1抗体.
- 在瘤查或随访期间没有发现恶性瘤.
- 患者在七个月后出现了临床改善和抗体血清阴性.
结论:
- 这是首个报告的抗SOX1抗体与小儿科患者的水后感染相关的病例.
- 这些发现扩大了已知的抗SOX1抗体相关神经系统疾病的临床谱.
- 抗SOX1抗体可以发生在儿童的非瘤神经疾病中,即使在病毒感染后.
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