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短间隔的第二次射精改善了精子质量,在ICSI循环中,在小精细精子雄性中形成了胚芽细胞:一个时间缩短的兄弟卵子细胞研究
Yaoxuan Li1, Shikai Wang1, Dawen Li1
1Reproductive Medical and Genetic Center, The People's Hospital of GuangXi Zhuang Autonomous Region, Nanning, China.
Frontiers in endocrinology
|September 25, 2023
概括
短间隔的第二次射精显著改善了精子质量和胚芽细胞的形成,对于经历了细胞内精子注射 (ICSI) 的小精子精子精子的男性. 这种简单的策略可以提高ICSI治疗结果.
科学领域:
- 生殖医学 生殖医学
- 安德罗学与人类学
- 胚胎学 胚胎学
背景情况:
- 以低精子数量和运动性为特征的Oligoasthenozoospermia,在辅助生殖技术的成功成果方面提出了挑战.
- 内细胞质精子注射 (ICSI) 是男性不孕症的常见治疗方法,但优化精子质量仍然至关重要.
研究的目的:
- 为了调查短间隔的第二次射精是否会改善精子质量,胚胎发育,以及在接受ICSI的男性患有小精细精的临床结果.
- 在ICSI周期中评估利用第二次射精中的精子的效率和临床价值.
主要方法:
- 患有橄酸精子症的男性患者在卵细胞检索当天经历了短间隔的第二次射精.
- 来自第一个和第二次射精的精子被用于单独的ICSI周期,其中786个兄弟卵子被平等地分成两组.
- 两个组之间的精液参数,胚胎发育,形态动力学和临床结果进行了比较.
主要成果:
- 第二次射精显著改善了精子的运动性,正常形态和DNA完整性.
- 在第二次射精的精子中观察到更高的高质量芽细胞,可用芽细胞和卵细胞利用率 (P<0.05).
- 虽然第二次射精组的临床怀孕,植入和活产率较高,但这些差异在统计学上并不显著 (P>0.05).
结论:
- 短间隔第二次射精是一种简单的,非侵入性的方法,可以提高精子质量在精子精子的男性.
- 这种技术可以提高胚胎细胞形成的效率,这表明有可能获得更好的ICSI治疗结果.
- 这些发现支持使用第二次射精作为优化ICSI成功率的有效策略.
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