血清25-基维生素D与老年男性尿失禁的相关性:基于NHANES 2007-2014年的证据
Li Liu1, Mingming Xu1, Hang Zhou1
1Department of Urology, Tianjin Medical University General Hospital, Tianjin, China.
Frontiers in endocrinology
|September 25, 2023
概括
低维生素D水平与老年男性的压力和混合性尿失禁风险增加有关. 这项研究研究了血清25-基维生素D与50岁以上男性的失禁之间的联系.
科学领域:
- 老年学是一门学科.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 内分泌学 在内分泌学.
背景情况:
- 血清25-基维生素D (25(OH) D) 与老年男性尿失禁亚型之间的关系尚未得到充分证实.
- 尿失禁显著影响老年男性的生活质量.
研究的目的:
- 调查血清25(OH) D水平与50岁及以上男性尿失禁患病率之间的相关性.
- 确定维生素D状态是否是老年男性不同类型尿失禁的危险因素.
主要方法:
- 利用了国家健康和营养检查调查 (NHANES) 的四个周期 (2007-2014) 的数据.
- 通过自我报告问卷评估尿失禁.
- 使用标准化液体染色学-并联质谱法 (LC-MS/MS) 量化血清25(OH) D.
- 使用加权的多因素物流回归分析来探索关联,控制共变量.
主要成果:
- 在分析中包括4663名老年男性.
- 无变量分析表明,维生素D缺乏的个体与足够的个体相比,所有三种尿失禁类型的几率都更高.
- 在对共变量进行调整后,维生素D缺乏仍然与压力尿失禁 (SUI) 和混合尿失禁 (MUI) 的几率增加有关.
结论:
- 较低的血清25(OH) D水平与老年男性的压力尿失禁和混合尿失禁有关.
- 这些发现表明,维生素D在老年男性尿失禁的病理生理学或管理方面可能发挥作用.
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