疼痛灾难化与减少神经对金钱奖励的反应有关
Megan E Cooke1,2,3, Robert R Edwards3,4, Grace L Wheeler1,2
1Center for Addiction Medicine, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, United States.
Frontiers in pain research (Lausanne, Switzerland)
|September 25, 2023
概括
疼痛灾难化与大脑奖励处理的改变有关,特别是在条纹体中杀激活,独立于疼痛强度或抑郁. 这表明,在疼痛中奖励功能障碍直接与灾难化有关.
科学领域:
- 神经科学是一个神经科学.
- 心理学 心理学 心理学
- 疼痛研究 疼痛研究
背景情况:
- 疼痛灾难化涉及对疼痛的负面评估,是疼痛干预中治疗目标.
- catastrophizing 疼痛的神经相关的研究不足.
- 在疼痛的成年人中观察到中皮层临回路中的奖励处理发生变化.
研究的目的:
- 为了研究疼痛灾难化和奖励任务期间神经激活之间的关联.
- 为了检查疼痛灾难化量表 (PCS) 分数与大脑对金钱激励的反应之间的关系.
- 探索疼痛的灾难性作用奖励功能障碍在个人疼痛,失眠和情绪症状.
主要方法:
- 使用了货币激励延迟 (MID) 神经成像任务.
- 评估了94名患有不同疼痛,失眠和情绪症状的成年人.
- 相关疼痛灾难化量表 (PCS) 得分与神经激活模式.
主要成果:
- PCS得分,而不是疼痛强度,在MID任务期间与尾状和形肌的形激活显著相关.
- 调解分析显示,PCS得分完全调解了抑郁症状和奖励激活之间的联系.
- 研究结果表明,疼痛灾难化与变化的条纹功能之间存在独立的关联.
结论:
- 疼痛灾难化独立地与经历疼痛的个体中变化的条纹功能有关.
- 疼痛条件中的奖励功能障碍与疼痛灾难化直接相关.
- 这些结果强调了疼痛灾难化是疼痛群体神经奖励处理变化的关键因素.
关键词:
紧紧跟在后面的时间.抑郁 抑郁症 抑郁症 抑郁症 是一种功能磁力共振成像 (fMRI) 是一种功能共振成像.货币激励措施的延迟疼痛 疼痛 疼痛 疼痛普塔门 (Putamen) 是一个名为普塔门的城市.更多相关视频
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