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在睡眠剥夺后的NREM神经睡眠中睡眠启动的变化 - 一个多式模式试点研究

E Miletínová^1,2, M Piorecký^1,3, V Koudelka^1,3

¹National Institute of Mental Health, Topolova 748, Klecany, Czech Republic.

Sleep medicine: X

|September 25, 2023

概括

兴奋障碍 (DOA) 患者在睡眠-清醒过渡期间表现出大脑连接的改变,即使在典型事件之外. 这表明DOA的潜在特征因子,在睡眠剥夺后影响皮质下和皮质功能.

科学领域:

神经科学是一个神经科学.
睡眠医学睡眠医学
脑部成像脑部成像

背景情况:

兴奋障碍 (DOA) 或NREM睡眠障碍,涉及睡眠和清醒过渡期间的异常运动和自主活动.
假设睡眠和清醒之间的分离状态会导致DOA症状.

研究的目的:

为了研究D.O.A患者在异眠事件之外的潜在解离性状态.
通过同时使用EEG和fMRI来探索入睡和唤醒期间的大脑活动和连接.

主要方法:

同时使用256通道高密度EEG (hdEEG) 和功能性MRI (fMRI).
八名DOA患者和八名健康对照人接受了睡眠剥夺,随后进行了hdEEG/fMRI记录.
数据使用多模式方法进行分析,整合了EEG,fMRI和EEG-fMRI.

主要成果:

在DOA患者的兴奋过程中,在特定的大脑区域,delta和beta活动增加.
在DOA患者在兴奋期间 (β频段) 观察到运动皮层和带状皮层之间的连接性增加.
DOA患者表现出 cingulum 内以及thalamus 和皮质区域之间的连接性发生变化.

结论:

研究结果表明,DOA患者在皮下和皮质水平上睡眠和唤醒机制的复杂变化.
这些变化甚至发生在慢波睡眠和异常睡眠期间之外.
观察到的大脑活动模式可能代表DOA的特征因素.

关键词:

兴奋的障碍兴奋的障碍功能性大脑成像 - 功能性脑成像 HdEEG 和 fMRI 的整合.高密度电脑电脑电图 (EEG) 是一种高密度电脑电图.帕拉索姆尼亚斯 (Parasomnias) 是一个令人难以置信的现象.慢波睡眠是一种缓慢的睡眠.

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