转移性激素敏感前列腺癌的口服化疗剂:随机对照试验的网络元分析
Yong Seong Lee1, Seong Hwan Kim2, Jong Hyun Tae3
1Department of Urology, Chung-Ang University Gwangmyeong Hospital, Chung-Ang University College of Medicine, Gyeonggi-do, Korea.
Prostate international
|September 25, 2023
概括
与标准治疗相比,新的口服化疗组合显著提高了转移性激素敏感前列腺癌 (mHSPC) 的存活率. 这些先进疗法为mHSPC患者提供更好的整体存活率 (OS) 和无进展存活率 (PFS).
科学领域:
- 在瘤学瘤学.
- 医学研究 医学研究
- 临床试验 临床试验
背景情况:
- 转移性荷尔蒙敏感前列腺癌 (mHSPC) 经常被用抗雄激素剥夺疗法 (ADT) 治疗.
- 口服化疗剂越来越多地与ADT结合用于mHSPC.
- 随机对照试验 (RCT) 已经证明了这些组合疗法的益处.
研究的目的:
- 为了比较各种口服化疗剂的整体生存 (OS) 和无进展生存 (PFS) 的好处,在mHSPC患者中与ADT一起使用.
- 根据标准护理 (SOC) 对新型口服药物的疗效进行评估.
主要方法:
- 在主要数据库 (PubMed,Embase,科学网,Cochrane图书馆,Scopus) 中对RCT进行系统文献审查.
- 由两个审查员进行独立选和数据提取.
- 对偏差风险的重复评估.
主要成果:
- 分析了18个涉及13,509名患者的RCT.
- 几种组合,包括ADT + 亚比拉和ADT + 恩扎胺,比SOC更好地改善了OS.
- 大多数治疗方法改善了PFS,除了ADT + 双胺单疗法和某些三重疗法等例外.
结论:
- 新的口服化疗剂组合应取代当前的ADT单疗法和ADT + docetaxel SOC用于mHSPC.
- ADT + docetaxel与雄激素受体向剂 (ARTA) 三重疗法需要进一步调查,因为它不是顶级治疗方法之一.
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