使用电子鼻子检测肺移植患者的细菌殖民
Nynke Wijbenga1,2, Nadine L A de Jong1,2,3, Rogier A S Hoek1,2
1Department of Respiratory Medicine, Erasmus University Medical Center Rotterdam, Rotterdam, the Netherlands.
Transplantation direct
|September 25, 2023
概括
电子鼻子 (eNose) 技术在肺移植接受者 (LTRs) 中的细菌殖民 (BC) 的非侵入性检测方面显示出前景. 这种呼吸分析工具实现了高精度,可能减少了侵入性支气管镜检查的需要.
科学领域:
- 肺部医学 肺部医学
- 移植手术 移植手术
- 生物技术是生物技术.
背景情况:
- 下呼吸道的细菌殖民 (BC) 在肺移植接受者 (LTRs) 中很普遍.
- BC增加了慢性肺异位移植功能障碍的风险.
- 目前的诊断通常需要侵入性支气管镜检查.
研究的目的:
- 评估电子鼻子 (eNose) 技术的诊断准确性,用于在LTR中非侵入性检测BC.
- 评估呼气分析作为替代诊断方法的潜力.
主要方法:
- 在前性,单中心队列研究中的横截面分析.
- 在门诊诊所从LTR收集的eNose测量.
- 监督机器学习和接收器运行特征分析用于评估诊断准确性.
主要成果:
- 最初包括161名LTR;分析了81名患者.
- 16名患者 (20%) 患有BC,65名 (80%) 没有.
- eNose在曲线下的面积为0.82 (训练组) 和0.97 (验证组).
结论:
- 使用eNose技术的呼气分析表明,在LTR中非侵入性BC检测具有显著的潜力.
- 与支气管镜检查相比,这种技术可能提供一种不那么侵入性的诊断方法.
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