在移植接受者中使用-葡萄糖共传输体-2 抑制剂
Pavithra Ramakrishnan1, Neetika Garg2, Samantha Pabich2
1Department of Medicine, University of Minnesota, Minneapolis, MN 55455, United States.
World journal of transplantation
|September 25, 2023
概括
-葡萄糖共传输体-2 抑制剂 (SGLT2i) 对移植接受者 (KTR) 是安全有效的. 这些药物在控制血糖和功能方面显示出短期益处,在KTR中观察到的不良事件率较低.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 药理学 药理学是指药理学的学科.
- 移植 移植 移植 移植
背景情况:
- -葡萄糖共传输体-2 抑制剂 (SGLT2i) 是已确立的糖尿病慢性病 (CKD) 和心力衰竭的治疗方法.
- 它们在移植接受者 (KTR) 中的使用是临床研究的一个新兴领域.
研究的目的:
- 审查目前关于SGLT2抑制剂在移植接受者的安全性和有效性的证据.
- 突出有关特定SGLT2抑制剂,患者特征和观察结果的关键发现.
主要方法:
- 关于在KTRs中使用SGLT2抑制剂的现有文献的审查.
- 对Empagliflozin的数据分析,这是这个人群中最常被处方的SGLT2i.
- 对血糖控制,功能和安全参数的短期影响的评估.
主要成果:
- 恩帕格利弗洛辛经常用于KTRs,通常在移植后3年开始,平均eGFR为66.7mL/min/1.73m2和HgbA1c为7.7%.
- 短期使用证明了提高HgbA1c,eGFR,血红蛋白/血红素和血清尿酸/的疗效.
- 发现SGLT2i在KTR中是安全的,感染率低,低血糖,euglycemic糖尿病酸性脂肪酸症和稳定的塔克罗利斯水平.
结论:
- SGLT2 抑制剂似乎对精选的移植接受者来说是安全有效的.
- 进一步的长期研究对于充分阐明患者,移植和心血管结果至关重要.
- 目前的证据支持SGLT2i作为KTR管理的宝贵补充,基于CKD患者的可靠数据.
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