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Updated: Jul 15, 2025

Characterizing Histone Post-translational Modification Alterations in Yeast Neurodegenerative Proteinopathy Models
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Characterizing Histone Post-translational Modification Alterations in Yeast Neurodegenerative Proteinopathy Models

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缺陷的RNA结合并不能阻止FUS ALS/FTD酵母模型中的基斯修饰变化

Seth A Bennett1, Samantha N Cobos2, Elizaveta Son3

  • 1PhD. Program in Biochemistry, City University of New York - The Graduate Center, New York, NY, USA 10016.

microPublication biology
|September 25, 2023
PubMed
概括

FUS蛋白突变导致神经退行性疾病. 即使没有结合RNA,FUS蛋白质的变化仍然会改变与这些条件相关的质子修饰.

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相关概念视频

RNA Stability01:53

RNA Stability

Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
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