升高的CK-MB水平与急性胰腺炎的不良临床结果有关:一种倾向性得分匹配的研究
Xiao-Ting Jiang1, Ling Ding1, Xin Huang1
1Department of Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
在急性胰腺炎 (AP) 患者中,肌酸激酶-心肌带 (CK-MB) 水平升高与增加的死亡率和严重疾病有关. 这一发现表明CK-MB可能成为AP中不良结果的有价值预测指标.
科学领域:
- 心脏病学 心脏病学
- 胃肠病学 胃肠病学
- 生物化学 生物化学
背景情况:
- 心脏损伤是急性胰腺炎 (AP) 的常见并发症.
- 心脏损伤,特别是肌动脉激酶-肌动脉带 (CK-MB) 水平升高对AP结果的影响需要进一步调查.
- CK-MB是一种生物标志物,主要存在于心肌中.
研究的目的:
- 评估CK-MB水平升高与AP患者不良临床结果之间的关联.
- 确定CK-MB升高是否是AP中不良结果的独立风险因素.
主要方法:
- 在4802名AP患者中进行了一项倾向分数匹配的研究.
- 通过倾向性得分匹配和多变量逻辑回归来分析数据.
- 评估了CK-MB水平,高水平被定义为>24U/ml.
主要成果:
- 在招募的患者中,18.66%的CK-MB水平升高.
- 在匹配的队列中,升高的CK-MB与较高的死亡率 (OR,5.87),严重急性胰腺炎 (SAP) (OR,2.74) 和感染性瘤性胰腺炎 (INP) (OR,3.40) 有显著关联.
- 多变量分析证实CK-MB的升高是增加死亡率的独立预测因素 (OR,2.753),SAP (OR,2.223) 和INP (OR,1.913).
结论:
- 升高的CK-MB水平与AP患者的不良结果显著相关.
- CK-MB升高可能作为一个有用的实验室参数,用于预测AP的不良临床结果.
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