索达里奥基因组:一个不断扩大的资源与大数据挖掘进化基因组学和转录基因组学
Zheng Wang1, Wonyong Kim2, Yen-Wen Wang1
1Department of Biostatistics, Yale School of Public Health, New Haven, CT, United States.
Frontiers in fungal biology
|September 25, 2023
概括
基因组学和转录学揭示了真菌的进化. 索尔达里奥基因组类,具有广泛的奥米克数据,为研究特征多样性和扩展大数据时代进化基因组学的模型提供了一个模型.
科学领域:
- 菌类进化基因组学 菌类进化基因组学
- 系统生物学 系统生物学
- 基因组学和转录基因组学
背景情况:
- 奥米克斯数据和技术进步已经改变了真菌模型系统.
- 索尔达里奥米塞特类是丰富的物种,生态多样化,经济重要,有着强大的研究历史.
- 已经测序了超过3,574种Sordariomycetes物种,占可用的ascomycete基因组的很大一部分.
研究的目的:
- 审查最近对Sordariomycetes的研究,整合遗传和生物数据,对真菌进化产生新的见解.
- 探索多物种研究如何解决基于有限模型基因组的研究局限性.
- 提出Sordariomycetes作为一个核心的奥米克类,以推进基因组规模的进化研究.
主要方法:
- 在Sordariomycetes中对遗传,致病和生物特征的综合分析.
- 跨不同血统的基因表达的祖先状态分析.
- 系统生物分析大数据从omics数据集.
主要成果:
- 研究已经推断出调控网络模型,并确定了真菌性发育中的关键遗传元素.
- 通过omics数据研究了状芽和二次新陈代谢的调节.
- 证明了多种物种研究对理解真菌进化基因组学的价值.
结论:
- 索尔达里奥米塞特类为扩大模型系统概念超越单个物种提供了一个强大的框架.
- 丰富的奥米克斯数据和强大的研究社区将索尔达里奥米塞特定位为未来进化研究的蓝图.
- 这种方法促进了在大数据时代跨真菌血统的特征多样性和演变的研究.
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