新出现的威胁是人类,动物和环境中抗真菌耐药的Candida tropicalis
Ricardo Lima1, Felipe C Ribeiro1, Arnaldo L Colombo1
1Special Mycology Laboratory, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
Frontiers in fungal biology
|September 25, 2023
概括
在Candida tropicalis中抗真菌耐药性是全球日益关注的问题. 本综述考察了抵抗机制,并使用"一健康"视角在人类,动物和环境中传播.
科学领域:
- 菌类学 菌类学是指菌类学.
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 抗真菌耐药性是人类,动物和环境健康的重大新兴威胁.
- 热带菌 (Candida tropicalis) 是一种广泛传播的真菌物种,导致感染,特别是亚洲和拉丁美洲的候选病,死亡率高.
- 在多个地区观察到的Fluconazole耐药性和C. tropicalis的克隆传播,巴西有关动物和环境中醇耐药性的报告令人担忧.
研究的目的:
- 审查和总结当前关于Candida tropicalis.抗真菌耐药性的知识.
- 探索C. tropicalis中抗真菌耐药性背后的分子机制.
- 采用"一个健康"的方法,整合人类,动物和环境对C. tropicalis抗真菌耐药性的观点.
主要方法:
- 对Candida tropicalis抗真菌耐药性研究的文献综述.
- 对抗性的分子机制的分析.
- 整合来自临床,动物和环境来源的数据.
主要成果:
- 热带菌 (Candida tropicalis) 表现出各种适应机制来发展抗真菌耐药性.
- 流可纳耐药性在某些地理区域普遍存在,特别是亚洲.
- 目前,C. tropicalis的多药性耐药性很少见,但正在增加,这引起了严重的临床关注.
结论:
- 热带菌 (Candida tropicalis) 具有复杂的抗真菌耐药性分子装置.
- 耐药菌株在人类,动物和环境水库中的传播需要协调的"一健康"战略.
- 持续的监测和研究对于打击C. tropicalis.抗真菌耐药性日益严重的威胁至关重要.
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