与急性白血病相关的保护性孕产妇营养素的同时摄入可能因性别而改变,在2岁以下的儿童中
Ángel Mérida-Ortega1, María Luisa Pérez-Saldivar2, Laura E Espinoza-Hernández3
1Center of Population Health Research, Instituto Nacional de Salud Pública (INSP), Cuernavaca, Mexico.
Frontiers in oncology
|September 25, 2023
概括
怀孕期间母亲的营养摄入量可能会降低婴儿急性白血病 (AL) 风险,特别是在女孩身上. 这项研究检查了同时摄入的营养素,为饮食和儿童癌症预防提供了新的见解.
科学领域:
- 流行病学 流行病学
- 营养科学 营养科学
- 儿科瘤学 儿科瘤学
背景情况:
- 怀孕期间母亲的饮食与婴儿急性白血病 (AL) 有着不清楚的联系.
- 以前的研究通常分析单个营养素,而不是反映现实世界的饮食模式.
- 同时摄入营养素可以提供对母亲饮食影响的更准确的评估.
研究的目的:
- 调查怀孕期间母亲同时摄入营养素与墨西哥两岁以下儿童的AL之间的关联.
- 探索这种关联中潜在的基于性别的差异.
主要方法:
- 在墨西哥城大都市区 (2010-2019) 进行了一项病例控制研究.
- 包括110个AL病例和252个对照.
- 通过使用食物频率问卷评估母亲摄入32种营养素;重量定量总数回归确定了营养素模式.
主要成果:
- 同时摄入营养素和AL之间的负相关性仅在女孩中观察到 (OR 0.17;95% CI 0.03,0.88).
- 没有发现同时摄入营养素和AL之间的积极关联.
- 这表明营养素的综合作用至关重要,而不是单独的营养素.
结论:
- 这项研究是首次强调,当考虑同时摄入时,与AL风险相关的营养素可能会有所不同.
- 母亲的饮食,特别是营养素的组合,可能会在女婴中起到保护性作用,防止AL.
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