COVID-19对肺移植接受者的长期肺功能的影响:单中心回顾性队列研究
Brice Touilloux1,2, Matthaios Papadimitriou-Olivgeris3, Cédric Bongard1
1Division of Pulmonary Medicine, Department of Medicine, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.
严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 感染暂时影响肺移植 (LT) 接受者的肺功能. 在COVID-19后的12个月内,LT接受者的肺功能得到改善,没有观察到长期显著下降.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 移植手术 移植手术
背景情况:
- 在接受肺移植 (LT) 患者中,SARS-CoV-2感染后长期肺功能 (LF) 的数据有限.
- 了解COVID-19对LT接受者的影响对于移植后的护理至关重要.
研究的目的:
- 评估第一个SARS-CoV-2感染对LT接受者的长期LF的影响.
- 在感染后的3,6个月和12个月分析螺旋测量变化.
主要方法:
- 对感染SARS-CoV-2的LT接受者的螺旋计数据的回顾性分析.
- 包括42名患有COVID-19的LT接收者,数据收集自2020年3月至2022年7月.
- 感染后3个月,6个月和12个月的强迫呼吸量 (FEV1) 和强迫生命能力 (FVC) 的评估.
主要成果:
- 在SARS-CoV-2感染后3个月观察到FEV1的显著下降 (-4.5%,-97毫升,p <.01).
- 富邦金融公司的趋势与FEV1相似,在3个月后显著下降.
- 感染后6个月或12个月没有发现螺旋计值的显著下降,这表明恢复.
结论:
- 首次感染SARS-CoV-2导致LT接受者肺功能显著但暂时下降.
- 在LT接受者的肺功能通常在COVID-19后12个月后恢复.
- 需要进一步的研究,以了解这种脆弱人群的长期影响.
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