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对过敏性食品污染物的反应性:对市场上产品的研究
Alessandro Fiocchi1, Linda Monaci2, Elisabetta De Angelis2
1Allergy Dpt, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Clinical and translational allergy
|September 25, 2023
概括
患有严重食物过敏的儿童容忍的过敏原水平高于建议的预防性标签. 这表明,目前牛奶和子的参考剂量可能过于谨慎,支持粮农组织/世卫组织的建议.
科学领域:
- 食物过敏研究 食物过敏研究
- 过敏性评估对过敏性的评估.
- 消费者安全 消费者安全
背景情况:
- 不故意的食物过敏原污染对过敏消费者构成风险.
- 关于预防性过敏原标签 (PAL) 门进行了讨论,VITAL ED01和粮农组织/世卫组织编码的水平不同.
- 评估过敏个体的实际耐受性水平对于准确的标签至关重要.
研究的目的:
- 评估严重食物过敏儿童对商业产品中牛奶和子含量的反应性.
- 将观察到的耐受性水平与现有的VITAL和粮农组织/世卫组织参考剂量进行预防性过敏原标签的比较.
主要方法:
- 口服食品挑战 (OFC) 使用没有子的饼干和没有牛奶的praline进行.
- 确诊患有子或牛奶严重过敏的患者参与了这项研究.
- 使用质谱测量量过敏原污染的数量.
主要成果:
- 吃饼干的桃过敏患者或吃praline的牛奶过敏患者没有观察到过敏反应.
- pralines 中的牛奶污染在 8-35 毫克/公斤之间,超过 VITAL ED01 的 1.5-10 倍.
- 在测试的饼干中没有检测到子污染.
结论:
- 严重食物过敏的个体可以耐受比VITAL目前建议的更高的过敏原剂量.
- 这些发现支持粮农组织/世卫组织推的较高参考剂量的安全性.
- 目前的PAL指南可能过于严格,可能会影响过敏消费者的食物供应.
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