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血管控制试验的变化灵敏度和临床重要差异最小
Lauré M Fijen1,2,3, Carolina Vera2,3, Thomas Buttgereit2,3
1Department of Vascular Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Clinical and translational allergy
|September 25, 2023
概括
血管控制试验 (AECT) 有效地测量了复发性血管控制的变化. 对AECT的三点改善意味着对患者来说具有临床重要意义的差异,提高了疾病管理.
科学领域:
- 临床评估 临床评估
- 患者报告的结果.
- 罕见疾病管理 罕见疾病管理
背景情况:
- 血管控制试验 (AECT) 是针对复发性血管的经过验证的患者报告的结果测量方法.
- 之前的研究还没有确定AECT对变化的敏感性或其最小临床重要差异 (MCID).
研究的目的:
- 为了确定AECT对复发性血管患者变化的敏感性.
- 在评估疾病控制方面为AECT建立MCID.
主要方法:
- 患有复发性血管的患者在例行访问期间完成了AECT,AE-QoL,DLQI和疾病控制.
- 对变化的敏感性是通过将AECT得分变化与变化相关联来评估的.
- 使用基于和分布式方法来确定MCID.
主要成果:
- AECT得分与AE-QoL和其他标有很好的相关性,证实了对变化的敏感性.
- 改善血管控制的MCID被确定为三个点.
- 没有足够的数据来确定恶化的MCID.
结论:
- AECT是跟踪复发性血管患者疾病控制变化的一个有价值的工具.
- 对AECT的三点变化代表了患者疾病控制的有意义的改善.
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