介质素-10与阻塞性睡眠呼吸暂停低呼吸综合征无关:一个元分析和元回归
Xiaoyan Li1, Lingyun Wu1, Jie He2,3
1School of Nursing, Zhejiang Chinese Medical University, Hangzhou, China.
Medicine
|September 25, 2023
概括
阻塞性睡眠呼吸暂停下垂症综合征 (OSAHS) 患者和健康人群之间,介乐10 (IL-10) 水平没有差异. 这次元分析发现IL-10和OSAHS在各个子组之间没有显著的关联.
科学领域:
- 医学研究 医学研究
- 睡眠医学 睡眠医学
- 免疫学 免疫学 免疫学
背景情况:
- 调查互白素-10 (IL-10) 和阻塞性睡眠呼吸暂停下垂症综合征 (OSAHS) 之间的潜在联系.
- 了解免疫标志物在与睡眠有关的呼吸系统疾病中的作用.
研究的目的:
- 为了确定IL-10水平是否与OSAHS有关.
- 进行元分析和生物信息学分析来探索这种关系.
主要方法:
- 在多个数据库 (EMBASE,PubMed等) 中进行全面的文献搜索. 在2022年10月之前.
- 使用 Stata 11.0 的元分析来计算标准平均差异 (SMD) 和置信区间 (CI).
- 对基因表达综合 (GEO) 数据集 (GSE38792,GSE135917) 的生物信息学分析,用于脂肪组织中的IL-10mRNA表达.
主要成果:
- 分析显示,OSAHS患者和对照组之间血或血清IL-10水平没有显著差异 (SMD = -0.68,P = .136;SMD = -0.12,P = .591).
- 基于种族,BMI,年龄,研究类型和疾病严重程度的亚组分析也没有显示出明显的差异.
- 生物信息学分析表明,小组之间的皮下和内脏脂肪组织IL-10mRNA表达没有显著差异.
结论:
- 这一元分析得出结论,在OSAHS患者和健康个体之间,IL-10水平没有显著差异.
- 这些发现表明IL-10可能不是OSAHS的可靠生物标志物.
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