在重离子治疗中使用子瘤标志物进行范围验证
E Kasanda1,2, V Bildstein1, D Hymers1,3
1Department of Physics, University of Guelph, 50 Stone Rd E, Guelph, Ontario, N1G 2W1, Canada.
Physics in medicine and biology
|September 25, 2023
概括
使用子瘤标记物 (HTMs) 的新方法估计了患者的重离子束范围. 测量HTM的马射线辐射提供了精确的范围验证,提高了癌症治疗的准确性.
科学领域:
- 医学物理 医学物理
- 辐射瘤学 辐射瘤学
- 核医学就是核医学.
背景情况:
- 重离子疗法提供精确的剂量沉积,但受到范围不确定性的限制.
- 精确的范围验证对于优化治疗计划和最大限度地减少对健康组织的剂量至关重要.
研究的目的:
- 研究一种新的方法,用子瘤标记物 (HTMs) 来估计重离子束范围.
- 评估使用HTM特征性马射线辐射用于治疗期间实时范围验证的可行性.
主要方法:
- 在目标区域附近放置了一个子瘤标记物 (HTM).
- 由治疗性离子束诱导的HTM内部的核反应产生了特有的马射线辐射.
- 分析了两个不同的反应通道,以确定马射线强度的比率,与剩余光束范围相关.
主要成果:
- 一个使用16O离子束和银 (Ag) 作为HTMs的原理证明实验成功进行.
- 确定了107Ag(16O,x) 112Sb和107Ag(16O,x) 114Sb反应通道适合用于HTM应用.
- 使用两个反应通道将理论范围的不确定性降低到±290μm,在单通道测量 (0.5毫米尺度) 上显著改善.
结论:
- 在临床环境中,HTM技术为精确的重离子束范围验证提供了一个有前途的方法.
- 这种方法可以使治疗计划充分利用布拉格峰的急剧剂量下降,提高治疗疗效和患者安全.
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