在复杂的急性尾炎中短期术后静脉对口服抗菌疗法:试点非劣质随机试验
Edgar Lipping1,2, Sten Saar1,2, Arvo Reinsoo1,2
1Division of Acute Care Surgery, North Estonia Medical Centre, Tallinn, Estonia.
手术后的口服抗生素对复杂尾炎的静脉注射抗生素没有劣势. 这项试点研究发现类似的并发症率和住院时间,支持口服作为可行的替代品.
科学领域:
- 手术传染病手术传染病
- 临床药理学 临床药理学
- 胃肠道手术 胃肠道手术
背景情况:
- 目前的做法往往有利于静脉注射抗生素后尾切除复杂的尾炎.
- 有限的研究比较了口服与静脉注射抗生素在这个患者群体中的疗效.
- 假设:口服抗生素在感染并发症方面产生了与静脉注射治疗相似的结果.
研究的目的:
- 为了评估术后口服抗生素的非劣质性.
- 在复杂的尾炎管理中比较口服与静脉注射的抗生素疗法.
- 评估传染性并发症和住院时间.
主要方法:
- 试点,开放标签,前性随机对照试验.
- 成年患者患有复杂的尾炎 (,穿孔,) 被随机分类.
- 视切除术后24小时静脉注射与24小时口服抗生素的比较.
主要成果:
- 招募了104名患者;51名 (IV) 和53名 (口服) 患者完成了治疗.
- 在30天的术后并发症 (综合并发症指数) 中没有显著差异.
- 静脉注射和口服组之间的住院时间是可比的.
结论:
- 在24小时内,口服抗生素的效果与静脉注射疗法相比并非劣.
- 口服抗生素是复杂尾炎的安全有效替代品.
- 支持一个潜在的转向口服抗生素在尾切除术后的使用.
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