相对的大脑年龄与社会经济地位和青年焦虑/抑郁问题有关
Jacob W Cohen1, Bruce Ramphal1, Mariah DeSerisy2
1New York State Psychiatric Institute, Vagelos College of Physicians and Surgeons, Columbia University.
Developmental psychology
|September 25, 2023
概括
社会经济地位 (SES) 影响年轻人的大脑衰老. 较低的SES指标,如职业声望,与延迟大脑衰老有关,这可能解释了与精神病风险的联系.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 公共卫生 公共卫生
背景情况:
- 大脑年龄,一个生物大脑衰老的标志物,与成年人的精神疾病有关.
- 社会经济地位 (SES) 的组成部分会影响整个生命中的大脑发育和精神病风险.
- 童年和青春期是神经发育和许多精神疾病发病的关键时期.
研究的目的:
- 研究社会经济地位 (SES) 组成部分如何影响儿童和青少年的大脑衰老.
- 探索相对大脑年龄 (RBA) 与青年精神症状之间的关系.
- 确定在发育过程中将SES与精神病风险联系起来的潜在生物途径.
主要方法:
- 从健康大脑网络研究中重新分析了数据.
- 包括470名年轻人,年龄在5-17岁之间.
- 评估的SES组件:职业声望,公共援助,家长教育和收入与需求比率 (INR).
- 使用大脑形态和总体体积来量化相对大脑年龄 (RBA).
- 检查了RBA和儿童行为检查清单 (CBCL) 精神病症状之间的关联,控制共变量.
主要成果:
- 较低的RBA与较低的家长职业声望 (p = .01) 和较低的公共援助入学率 (p = .03) 相关.
- 父母的精神病诊断与较低的RBA (p = .01) 有关.
- 较低的父母职业声望和较低的RBA与较高的CBCL焦虑/抑郁分数相关 (p = .02和p = .04,分别).
结论:
- 社会经济地位 (SES) 的组成部分显著影响年轻人的大脑衰老轨迹.
- 延迟的大脑衰老 (较低的RBA) 可能是将SES与精神病风险增加联系起来的生物学机制.
- 纳入SES因素对于发育性大脑研究和理解精神疾病至关重要.
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