在儿童结核病的便样本中,基于卡的核酸放大测试 (CBNAAT) 的诊断准确性
Richa Singhal1, Rajeshwar Dayal2, Shailendra Bhatnagar3
1Department of Pediatrics, S.N. Medical College, Agra, 282003, India.
Indian journal of pediatrics
|September 25, 2023
概括
便卡基核酸放大测试 (CBNAAT) 显示了儿童结核病 (TB) 的高诊断准确性,与胃吸附CBNAAT相比. 这使得便CBNAAT成为诊断儿童结核病的可行替代方案.
科学领域:
- 儿童传染病 儿童传染病
- 微生物学 微生物学
- 诊断测试 诊断测试 诊断测试 诊断测试 诊断测试
背景情况:
- 儿童结核病 (TB) 的诊断可能具有挑战性.
- 胃吸附剂 (GA) 基于盒子的核酸放大测试 (CBNAAT) 是一种常见的诊断工具.
- 需要使用替代的,不那么侵入性的采样方法.
研究的目的:
- 为了评估便CBNAAT的诊断准确性,与GA CBNAAT相比,在可能患有结核病的儿童中.
- 为了确定CBNAAT与便和GA样本的结果之间的一致性.
主要方法:
- 一项横截面研究招募了100名患有假定结核病的儿童 (0-18岁).
- 用CBNAAT测试了胃吸血和便样本.
- 使用统计分析对诊断性能进行了比较.
主要成果:
- CBNAAT显示GA的诊断准确率为81%,便样本的诊断准确率为80%.
- 便和GA CBNAAT结果之间存在很高的一致性 (97%,科恩的卡帕=0.94).
- 灵敏度为75% (GA) 和73% (便);两者的特异性为100%.
结论:
- 便CBNAAT是一种高度准确和可比的GA CBNAAT替代品,用于诊断儿科结核病.
- 这种方法为在儿童中诊断肺结核和扩散结核病提供了不那么侵入性的选择.
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