从患有二次心肌病的患者中解剖心脏组织中的微量元素度
Ana Ćirović1, Aleksandra Buha Đorđević2,3, Aleksandar Ćirović4
1Faculty of Medicine, Institute of Anatomy, University of Belgrade, Dr Subotica 4/2, 11000, Belgrade, Serbia.
Biological trace element research
|September 25, 2023
概括
心肌病患者在心脏组织中显示出更高水平的,,和铜. 患有心肌病 (CMP) 的个体的必需水平显著降低.
科学领域:
- 心脏病学 心脏病学
- 毒理学 毒理学 毒理学
- 环境健康 环境健康
背景情况:
- 心肌病 (CMP) 是心力衰竭和移植的主要原因,长期结果不佳.
- 重金属是众所周知的心脏毒素,在心脏病患者的血液和尿液中观察到高水平.
- 在CMP中缺乏直接的心肌金属分析,特别是在 (Zn) 等必需金属方面.
研究的目的:
- 为了研究和量化CMP患者左心室心肌中的金属度.
- 为了比较CMP患者和非心脏病对照者的金属配置.
主要方法:
- 从52个个体中收集了死后左心室心肌样本.
- 19个样本来自被诊断为CMP的患者 (平均年龄为72±10岁).
- 33个样本来自没有心脏病的个人 (平均年龄67±15岁).
- 分析了金属度 (包括,,,铜和).
主要成果:
- 与对照组相比,CMP患者的,,和铜度明显高 (p ≤0.011).
- 在CMP受试者的心肌中,水平明显较低 (p = 0.017).
- 这些发现表明,CMP.个体心脏组织中的金属负担发生了变化.
结论:
- 心肌度增加的,,和铜与心肌病相关.
- 心脏中水平降低也可能在CMP病变发生过程中发挥作用.
- 这些结果突出了特定重金属的潜在心脏毒性作用以及必需矿物质对心脏健康的重要性.
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