TGFβ

Paige Miranda1, Anastasios A Mirisis1, Nikolay V Kukushkin1,2

  • 1Center for Neural Science, New York University, New York, NY 10003.

概括

转化生长因子β (TGFβ) 在Aplysia中充当长期记忆 (LTM) 的重复检测器. 它在第二次学习试验中的激活对于形成持久记忆至关重要.

相关概念视频

TGF - β Signaling Pathway01:16

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Long-term Potentiation01:35

Long-term Potentiation

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Long-term Depression01:03

Long-term Depression

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Amplifying Signals via Enzymatic Cascade01:22

Amplifying Signals via Enzymatic Cascade

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Enzyme-linked Receptors

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Activation and Inactivation of G Proteins01:22

Activation and Inactivation of G Proteins

Heterotrimeric G proteins are guanine nucleotide-binding proteins. As the name suggests, heterotrimeric G proteins are composed of three subunits: alpha, beta, and gamma. They remain GDP-bound or GTP-bound inside the cells and switch between inactive/active states. The Gα subunit possesses the nucleotide-binding pocket that binds guanine nucleotides and switches between GDP or GTP-bound states. In contrast, the Gꞵ and Gγ subunits are always bound together with high...
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