对患有轻微损伤多发性硬化症的人进行心肺运动测试
Vasiliki Apollonatou1, Dimosthenis Lykouras2, Odysseas Kargiotis3
12nd Pulmonary Medicine Department, Athens Medical School, "Attikon" University Hospital, National and Kapodistrian University of Athens, Athens, Greece; Department of Respiratory Medicine, University General Hospital of Patras, Patras, Greece.
心肺运动检测显示出多发性硬化症 (pwMS) 的门诊患者的功能障碍,即使没有呼吸系统症状. 建议对这一群体进行定期的肺功能评估,以检测潜在的妥协.
科学领域:
- 神经学 神经学
- 肺部病理学 肺部病理学
- 运动生理学 运动生理学
背景情况:
- 多发性硬化症 (MS) 是一种慢性中枢神经系统疾病,后期可能会影响呼吸功能.
- 患有多发性硬化症 (pwMS) 的出院患者可能会出现亚临床呼吸损害.
- 评估心肺功能和生活质量对于管理pwMS至关重要.
研究的目的:
- 为了评估呼吸功能和心肺运动测试 (CPET) 在门诊 pwMS.
- 调查CPET结果,生活质量和pwMS中的疲劳之间的关系.
- 为了确定在门诊 pwMS 中是否存在亚临床呼吸系统障碍.
主要方法:
- 一组25名pwMS和16名健康对照人接受了肺功能测试和CPET.
- 评估了最大的自愿通风,螺旋计和肺扩散能力.
- 使用SF-36问卷测量生活质量,使用MFIS评估疲劳.
主要成果:
- 虽然螺旋测量和肺扩散正常,但pwMS中最大自愿通风减少.
- 与对照组相比,CPET揭示了pwMS中氧气吸收峰值 (V'O2峰值),二氧化碳输出峰值 (V'CO2峰值) 和其他关键参数的显著损害.
- 降低的CPET值与BMI和疲劳 (MFIS) 有负相关性,与生活质量 (SF-36) 有正相关性.
结论:
- 患有多发性硬化症的门诊患者表现出受影响的心肺运动测试参数,无论呼吸道症状如何.
- 这些发现强调了在门诊PWMS中需要进行肺功能评估的必要性.
- 早期发现肺部损害可以为MS患者的管理策略提供信息.
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