在试管婴儿过程中对有或没有子宫内膜异位症的妇女进行疼痛评估:一项前性研究
Alice Cathelain1, Virginie Simon2, Jean Michel Wattier3
1CHU Lille, Departments of Assisted Reproductive Technologies and Fertility Preservation, Jeanne de Flandre Hospital, F-59000, Lille, France; CHU Lille, Gynaecology Surgery Department, F-59000, Lille, France.
Reproductive biomedicine online
|September 25, 2023
概括
患有子宫内膜异位症的患者在试管婴儿期间报告疼痛增加,但他们的疼痛水平保持稳定. 这凸显了在经过体外受精的不孕女性早期疼痛评估和管理的需要.
科学领域:
- 生殖医学 生殖医学
- 疼痛管理 疼痛管理
- 妇科 妇科医生 妇科
背景情况:
- 子宫内膜异位症显著影响女性的健康,经常导致慢性疼痛.
- 不孕症影响着大量女性,体外受精 (IVF) 是一种常见的治疗方法.
- 了解试管婴儿期间的疼痛经历对于患者护理至关重要.
研究的目的:
- 在整个试管婴儿过程中,调查无育患者和无子宫内膜异位症患者之间疼痛类型和强度的差异.
- 评估这些患者群体在试管婴儿治疗的不同阶段疼痛感知如何发展.
主要方法:
- 一项前性,观察性队列研究,涉及278名接受试管婴儿治疗的不育患者.
- 在三个关键时间点使用经过验证的尺度来评估疼痛:治疗前,刺激结束和卵细胞检索.
- 疼痛评分和疼痛表型 (包括神经病痛) 的比较, Endometriosis 和没有 Endometriosis 的患者之间.
主要成果:
- 与没有子宫内膜异位症的患者相比,子宫内膜异位症患者的基线疼痛得分 (3.47比1.12) 和神经病痛的患病率 (17.81%) 较高.
- 抑郁症 (22%比8%) 和焦虑症 (33%比20%) 等心理健康问题在患有子宫内膜异位症的患者中更为频繁.
- 虽然在没有子宫内膜异位症的患者中,IVF期间疼痛显著增加,但在患有子宫内膜异位症的患者中,疼痛仍然稳定.
结论:
- 子宫内膜异位症与接受试管婴儿治疗的不育患者的疼痛水平升高有关.
- 尽管初始疼痛较高,但子宫内膜异位症患者在试管婴儿周期期间没有经历明显的疼痛增加.
- 在试管婴儿前和试管婴儿期间查和描述疼痛表型对于所有不育患者的有效疼痛管理至关重要.
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