对早产风险因素的全面审查
Irene D Tang1, Daniel Mallia2, Qi Yan3
1Vagelos College of Physicians and Surgeons, Columbia University, New York, New York.
American journal of perinatology
|September 25, 2023
概括
预测早产是具有挑战性的,因为它的许多不同的风险因素. 一项全面的审查强调了需要采用整体方法来理解和潜在地预测这一关键的怀孕结果.
科学领域:
- 产科和妇科 产科和妇科
- 新生儿医学 新生儿医学
- 公共卫生 公共卫生
背景情况:
- 过早分娩是导致婴儿死亡和发病的主要原因.
- 过早分娩的潜在原因和可识别的风险因素在很大程度上是未知的.
- 现有的研究对众多孤立的风险因素提出了碎片化的观点.
研究的目的:
- 进行范围审查,绘制出早产所报告的各种风险因素.
- 综合现有的关于早产风险因素的文献.
- 确定当前研究中的挑战,并建议未来的方向.
主要方法:
- 在PubMed数据库中对过去五年内发表的文章进行了全面的搜索.
- 标题和摘要进行了资格审查,随后进行了全文审查.
- 抽取了已识别的风险因素的赔率比率和其他关联度.
主要成果:
- 最初总共有2,509篇文章被确定,最终包括314篇在分析中.
- 风险因素被分为活动,心理,病史,毒理学,遗传学和阴道微生物组.
- 报告了许多风险因素,但由于定义和分析方法不一致,合成变得复杂.
结论:
- 过早分娩与各种领域的多种不同的风险因素有关.
- 综合研究结果是具有挑战性的,因为研究设计和定义的异质性.
- 对于大型数据集需要先进的分析方法,以便更好地理解和预测早产.
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