在老年人中,身体活动水平与ATPase抑制因子1度之间的关联
Jérémy Raffin1, Yves Rolland2, Annelise Genoux3
1Institut du Vieillissement, Gérontopôle de Toulouse, Centre Hospitalo-Universitaire de Toulouse, Toulouse 31000, France.
Journal of sport and health science
|September 25, 2023
概括
定期体力活动 (PA) 与老年人中较高的腺三酸酶抑制因子1 (IF1) 水平有关,阿波利波蛋白AI (apoA-I) 部分调解了这种联系. 更高的IF1也预测了未来的PA下降.
科学领域:
- 老年学是一门学科.
- 代谢研究研究 代谢研究
- 运动生理学 运动生理学
背景情况:
- 氨酸三酸酶抑制因子1 (IF1) 对于能量代谢至关重要,并与年龄相关的疾病有关.
- 在老年人中,IF1和体力活动 (PA) 之间的关系尚不清楚.
- 受PA影响的Apolipoprotein A-I (apoA-I) 可能会调解IF1的作用,因为它们在ATP合成酶上有共同的结合位.
研究的目的:
- 调查老年人慢性PA和血IF1度之间的关联.
- 为了确定apoA-I是否调解PA和IF1之间的关系.
- 探索IF1度是否可以预测PA的后续变化.
主要方法:
- 从多域阿尔茨海默氏症预防试验中分析了1096名70岁以上的健康成年人.
- 每年测量PA度和IF1度.
- 用多个线性回归和调解分析来评估apoA-I的关联和调解.
主要成果:
- 较高的PA水平与IF1度积极相关 (p=0.043).
- ApoA-I 在这种关联中约占37.7% (p=0.023).
- 一年升高的IF1预测未来两年PA下降速度更快 (p=0.025).
结论:
- 正常的PA与老年人血IF1度有关,部分由apoA-I调解.
- 基线IF1水平可以预测未来体力活动的下降.
- 需要进一步的研究来阐明潜在的机制.
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