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对药物物质可提取物和可浸出物 (E&Ls) 的横读方法的协调

Melisa Masuda-Herrera1, Hannah T Rosen2, Anders Burild3

  • 1Gilead Sciences, Inc., Nonclinical Safety and Pathobiology (NSP), Foster City, CA, 94404, USA.

Regulatory toxicology and pharmacology : RTP
|September 25, 2023
PubMed
概括

对于可提取物和可浸出物 (E&Ls) 的新阅读方法有助于确定基于健康的暴露限值 (HBELs). 这种方法提供了一个健康保护框架,当特定的毒理学数据是有限的,特别是对于亲肠道药物产品.

关键词:
生物可用性 生物可用性可以提取的可提取物.液性食品可以液化.方法论 方法论 方法论制药公司 制药公司阅读横向的阅读.

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Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
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