围产和早期生活因素以及学龄前儿童的喘控制:基于人口的回顾性队列研究
Linn E Moore1, Jesus Serrano-Lomelin2, Rhonda J Rosychuk1
1Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
BMJ open respiratory research
|September 25, 2023
概括
防止儿童喘控制不良至关重要. 产前和生命早期的因素,如产前抗生素,剖腹产和妊娠期糖尿病,与幼儿的部分或不受控制的喘有关.
科学领域:
- 儿科肺病学 儿科肺病学
- 围产儿医学 围产儿医学
- 流行病学 流行病学
背景情况:
- 儿童喘控制对长期呼吸系统健康至关重要.
- 早期识别风险因素可以为预防策略提供信息.
- 围产期和生命早期的暴露与喘的发展和控制有关.
研究的目的:
- 评估围产期和早期生活因素与早期儿童喘控制之间的关联.
- 确定导致学龄前儿童部分或不受控制的喘的特定危险因素.
- 为旨在改善儿童喘结果的公共卫生倡议提供信息.
主要方法:
- 在加拿大阿尔伯塔省使用母亲和儿童 (2010-2012年出生) 的行政健康数据进行了回顾性队列研究.
- 包括在5岁之前被诊断患有喘的儿童,在诊断后2年内评估喘控制.
- 多项逻辑回归分析了围产期/生命早期因素与喘控制水平 (受控,部分受控,不受控制) 之间的关联.
主要成果:
- 在7206名患有喘的学前儿童中,52%患有控制喘,37%部分控制喘,12%患有失控喘.
- 与部分控制喘相关的因素包括产前抗生素,吸烟,剖腹产,夏季分娩和早期呼吸系统住院.
- 妊娠糖尿病,剖腹产,抗生素和早期呼吸系统住院病例与失控的喘有关.
结论:
- 母亲和早期生活因素,如抗生素使用,妊娠期糖尿病,吸烟,剖腹产,夏季分娩和呼吸系统住院,与儿童的喘控制不佳有关.
- 这些发现凸显了围产期健康和生命早期暴露在肺部发育和疾病规划中的关键作用.
- 在怀孕和幼儿时期针对这些可修改的风险因素的干预措施可以改善喘控制结果.
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