在患有多发性硬化症的患者中,在产节期的精神病并发症
Anibal S Chertcoff1, Fardowsa L A Yusuf1, Feng Zhu1
1From the Faculty of Medicine (Neurology) (A.S.C., F.L.A.Y., F.Z., Y.Z., H.T.), University of British Columbia and The Djavad Mowafaghian Center for Brain Health; School of Population and Public Health (F.L.A.Y.), University of British Columbia, Vancouver; College of Pharmacy and Nutrition (C.E.), University of Saskatchewan, Saskatoon; Nova Scotia Health and the Departments of Psychiatry, Psychology & Neuroscience, and Medicine (J.D.F.), Dalhousie University, Halifax; and Departments of Internal Medicine and Community Health Sciences (R.A.M.), Health Sciences Center, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.
精神病发病率,包括抑郁和焦虑,在多发性硬化症 (MS) 诊断的前几年是显着更常见的. 这种增加的负担表明精神疾病可能是MS发病的早期指标.
科学领域:
- 神经学 神经学
- 精神病学是一个精神病学.
- 流行病学 流行病学
背景情况:
- 精神病发病率是多发性硬化症 (MS) 诊断后的一个已知的并发症.
- 然而,精神病在预发性阶段 (MS发病前) 的患病率和影响在很大程度上仍未被描述.
研究的目的:
- 为了比较精神病发病率的患病率和相对负担,在后来发展MS的个人与MS发病前匹配的对照人群之间进行比较.
- 调查MS前期精神疾病的医疗保健利用模式.
主要方法:
- 利用了加拿大不列颠哥伦比亚省的相关行政和临床数据.
- 确定了多发性硬化病例,并将其与一般人口对照进行了匹配.
- 在MS发病前5年使用经过验证的定义和统计模型评估精神病发病率和医疗保健利用率.
主要成果:
- 与对照组相比,在诊断前5年内,患MS的个体表现出明显更高的精神病发病率 (14.9%与行政队列中的28.0%相比).
- 与对照组相比,MS发病前的MS病例表现出更多的医生访问,精神科医生咨询,住院治疗和精神药物处方.
- 这些差异在MS发病前一年特别明显.
结论:
- 精神病发病率在多发性硬化症的前阶段是一个巨大的负担.
- 增加的精神病发病率和相关的医疗保健利用率可能是MS前兆的潜在早期指标或特征.
相关概念视频
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Diagnostic and Statistical Manual of Mental Disorders (DSM)
Psychological and Sociocultural Causes of Schizophrenia
Bipolar Disorder
Biological Causes of Schizophrenia
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Schizophrenia


