在性别确认护理中的红细胞瘤与的治疗
Alana Tova Porat1, Meghan Ellwood2, Marisa Rodina2
1Virginia Commonwealth University, Richmond, Virginia poratat@vcu.edu.
Annals of family medicine
|September 25, 2023
概括
使用丸激素的性别肯定激素治疗很少导致严重的红细胞瘤. 这项研究发现血红素升高的发病率很低,这表明对某些患者来说,不那么频繁的监测可能是适当的.
科学领域:
- 内分泌学 在内分泌学.
- 血液学 血液学 血液学
- 跨性别者健康 跨性别者健康
背景情况:
- 性别确认激素治疗 (GAHT) 对变性人来说至关重要.
- 治疗是一种常见的GAHT形式,可能会增加血红蛋白和血红素,这种情况被称为二级红细胞瘤.
- 目前的指导方针建议频繁监测血红蛋白/血红素,可能会造成护理障碍.
研究的目的:
- 为了研究在最初的20个月的丸激素治疗期间发生的红细胞瘤的发病率,为性别确认的护理.
- 评估高血红蛋白和血红素水平在接受GAHT的个体中的频率.
主要方法:
- 进行了一项描述性的固定队列研究.
- 血红素和血红蛋白数据是从282个接受GAHT丸激素治疗的个体的医疗记录中收集的.
- 数据分析的重点是治疗的前20个月.
主要成果:
- 血红素超过50.4%的累计发病率在20个月内为12.6%.
- 在1.0%的个体中观察到高于52%的血红素值.
- 严重的红细胞瘤 (血值>54%) 仅在0.6%的参与者中发生.
- 所有参与者都接受了可注射的酸,平均剂量为每周100毫克.
结论:
- 严重的红细胞瘤是性别肯定性丸激素治疗的罕见副作用.
- 这些发现表明,目前在激素治疗的第一年进行频繁,常规的红细胞查的建议可能需要重新考虑.
- 对于寻求尽量减少抽血的患者,可以考虑不太频繁的实验室监测.
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