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视网膜薄化作为疾病严重性的标记在渐进性超核性麻中的标记

Yueting Chen^1,2, Haotian Wang¹, Bo Wang¹

¹Department of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

Journal of movement disorders

|September 25, 2023

概括

渐进性上核性麻 (PSP) 中的视网膜稀薄与疾病严重程度和大脑变化相关. 黄斑变薄可能表明PSP患者的多巴胺细胞退化.

科学领域:

神经科学是一个神经科学.
眼科医生眼科眼科
放射学放射学是一门学科.

背景情况:

渐进性超核性 (PSP) 呈现出视觉症状,可能与视网膜结构异常有关.
视网膜变化,疾病严重程度和PSP内变化之间的确切关系尚不清楚.

研究的目的:

在PSP患者中调查特定的视网膜稀释模式.
检查这些视网膜变化,临床严重程度和内变化之间的关联.

主要方法:

19名PSP患者和20名健康对照人接受了周周毛囊和黄斑区域的光学连贯性断层扫描 (OCT).
此外,PSP患者还使用11C-CFT和18F-FDG进行了正子发射断层扫描 (PET) 扫描.
分析了视网膜厚度,临床特征,条状多巴胺载体的可用性和大脑葡萄糖代谢之间的关联.

主要成果:

与对照人群相比,PSP患者表现出周周毛囊视网膜神经纤维层 (pRNFL) 和斑点显著稀薄.
较高的pRNFL厚度与运动和功能疾病严重程度等级负相关.
外部下角斑点厚度与疾病持续时间有负相关性,而外部时斑点厚度与认知评分有正相关性,与尾状多巴胺转运体结合有负相关性.

结论:

视网膜周周神经纤维层 (pRNFL) 和黄斑变薄可能作为监测PSP疾病严重程度的标志物.
黄斑变薄可能是PSP中尼格罗斯特里亚塔尔多巴胺基细胞退化的体内指标.

关键词:

18F-FDG 皮革皮革 (PET) 的使用斑点的厚度斑点的厚度光学连贯性断层扫描仪渐进性的超核性.视网膜神经纤维层是一种神经纤维层.

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