对长期对迷幻药物产生负面心理反应的案例分析
Rebecka Bremler1, Nancy Katati2, Parvinder Shergill2
1Centre for Psychedelic Research, Imperial College London, London, UK. r.bremler21@imperial.ac.uk.
Scientific reports
|September 25, 2023
概括
这项研究调查了对迷幻药物的负面心理反应,发现易受伤害的个体,特别是年轻人,在不良环境中使用迷幻药物时可能会出现恶化的精神症状或新的诊断.
科学领域:
- 心理药理学 心理药理学
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
背景情况:
- 迷幻药物正在探索其治疗潜力,但人们对结果的偏见报告存在担忧.
- 这项研究解决了调查对迷幻药物负面心理反应的需要.
- 专注于不良影响对于降低风险和了解全方位的迷幻体验至关重要.
研究的目的:
- 为了调查和表征心理药物使用的负面心理反应.
- 确定导致这些不良结果的潜在因果因素.
- 为心理使用的风险减轻策略提供信息.
主要方法:
- 通过社交媒体,招募的个人报告了长期的负面心理反应 (>72小时) 对迷幻药物 (经典迷幻药物和MDMA).
- 管理的在线调查问卷用于定量和定性数据收集.
- 与经历严重负面结果的个体进行半结构化采访,随后进行主题分析.
主要成果:
- 37.5%的初始完成者在使用幻化药后出现了新的精神病诊断; 87%的人经历了焦虑症状的恶化.
- 在接受采访的参与者中 (n=15),33%接受了新的精神病诊断,所有报告的症状恶化,主要是焦虑 (93%).
- 确定的潜在因果因素包括不利的环境,具有挑战性的急性经历,心理脆弱性,高/未知剂量和年轻年龄.
结论:
- 这项研究证实了与迷幻药物使用相关的精神健康转化发生.
- 一个常见的因果机制似乎涉及促进塑性药物的组合与不利的环境和/或心理脆弱性.
- 这些发现强调了需要谨慎和进一步研究的必要性,因为样本大小小和选择性重点.
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