紧张是皮肤对污染反应的关键因素
Erika Pambianchi1, Zachary Hagenberg1, Alessandra Pecorelli1,2,3,4
1Department of Animal Science, Plants for Human Health Institute, North Carolina State University, Kannapolis, NC, 28081, USA.
Scientific reports
|September 25, 2023
概括
臭氧污染增加了皮肤的污染.
科学领域:
- 环境毒理学环境毒理学
- 皮肤病学 皮肤病学
- 皮肤生理学 皮肤生理学
背景情况:
- 热带层污染,包括臭氧,对皮肤健康产生负面影响.
- 臭氧的高反应性对表皮脂质构成重大威胁.
- 研究污染对皮肤的影响需要先进的,相关的模型.
研究的目的:
- 调查臭氧暴露对全身系统的有害影响.
- 为了验证臭氧对皮肤抗微生物 (AMP) 的调节.
- 评估生理紧张对臭氧诱导的皮肤反应的影响.
主要方法:
- 使用了TenSkinTM模型,在生理紧张状态下对人体皮肤进行了ex vivo扩展.
- 暴露的皮肤暴露在臭氧中,以评估基因和蛋白质表达.
- 分析了抗微生物 (CAMP/LL-37,hBD2,hBD3) 和氧炎症标记物 (COX2,AhR,MMP9,4HNE).
主要成果:
- 在基因和蛋白质水平上,臭氧暴露显著上调AMP (CAMP/LL-37,hBD2,hBD3).
- 生理张力调节臭氧诱导的AMP表达.
- 在紧张和非紧张组之间观察到OxInflammatory标志物的明显反应.
结论:
- 通过氧化还原信号确认污染诱导的皮肤AMP表达.
- 突出了TenSkinTM模型对研究皮肤对环境压力因素的反应的实用性.
- 强调皮肤紧张在解释污染对皮肤影响的关键作用.
相关概念视频
Introduction to Stress and Lifestyle
139
Stress is a multifaceted response to events perceived as challenging or threatening, highlighting physical, emotional, cognitive, and behavioral reactions. Physically, stress can lead to fatigue, sleep disruptions, and various health issues such as frequent colds, chest pains, and nausea. Emotionally, it can manifest as anxiety, depression, irritability, and anger triggered by both minor and major life events. Cognitively, it may result in difficulty in concentration, memory, and...
139
Types of Toxins
1.7K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
1.7K
Asthma-I: Introduction
2.7K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.7K
Pigmentation
2.5K
The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
2.5K
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.8K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.8K
Factors Affecting Pulmonary Ventilation
1.4K
Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
1.4K


