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Updated: Jul 15, 2025

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
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Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid

Published on: September 20, 2017

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通过实验和分子模拟对药物-盐-聚合物相互作用进行比较分析,提高生物制药性能

Sumit Mukesh1, Goutam Mukherjee2,3, Ridhima Singh1

  • 1Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), S.A.S. Nagar, Sector-67, Mohali, Punjab, 160062, India.

Communications chemistry
|September 25, 2023
PubMed
概括

选择最佳的无形药物配方需要了解药物-盐-聚合物相互作用. 分子动力学模拟预测了稳定的药物聚合物系统,改善了诸如赛莱科西布这样的溶性较差药物的生物可用性.

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Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
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The physicochemical characteristics of drugs play a crucial role in formulating stable and bioavailable drug products. The solubility of a drug, governed by the varying pH along the GI tract and its dissociation constant (pKa), is pivotal in determining its ionization state and absorption rate. Notably, weak acids and bases remain unionized and are absorbed more rapidly.
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