来自甲原菌的病毒汇编揭示了它们的多样性和适应肠道环境的适应性
Sofia Medvedeva1, Guillaume Borrel2, Mart Krupovic3
1Institut Pasteur, Université Paris Cité, Unit Evolutionary Biology of the Microbial Cell, Paris, France.
Nature microbiology
|September 25, 2023
概括
这项研究揭示了大量未被发现的病毒多样性,它们感染了甲原始物. 这些病毒,特别是动物肠道中的病毒,表现出独特的适应性,并为新的遗传工具提供了潜力.
科学领域:
- 微生物学 微生物学
- 病毒学 病毒学
- 考古研究 考古研究
背景情况:
- 甲原始生物是各种生态系统 (包括动物肠道) 中的主要甲生产者.
- 感染这些古生物的病毒 (菌体) 尚不清楚,这限制了人们对它们生态作用的了解.
研究的目的:
- 进行全球对与甲原性古物种的全部多样性相关的病毒的调查.
- 描述这些古老病毒的遗传构成和潜在功能.
主要方法:
- 组装了一个广泛的CRISPR数据库 (156,000间隔器) 用于病毒识别.
- 分析病毒序列,包括 (亲病毒) 和病毒样/等离子体DNA.
- 将病毒分类为家族,并分析它们的遗传内容.
主要成果:
- 在10个甲基生物序列中确定了282个高质量的 (亲病毒) 和205个病毒样/等离子体序列.
- 发现了87个病毒家族,表明显著的未被发现的病毒遗传多样性.
- 在肠道相关的古生物和细菌的病毒中发现了融合进化,具有独特的 lysin 蛋白和遗传元素.
结论:
- 描述的病毒谱提供了对甲原体社区调节的见解.
- 这些发现为开发考古研究的新型遗传工具奠定了基础.
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