在2型糖尿病患者中,非酒精性脂肪肝病和受损内皮功能
Zeinab Montazeri1, Nahid Hashemi-Madani2, Hamed Iraji3
1Endocrine Research Center, Institute of Endocrinology and Metabolism, Department of Internal Medicine, School of Medicine, Iran University of Medical Science, Tehran, Iran.
BMC endocrine disorders
|September 25, 2023
概括
非酒精性脂肪性肝病 (NAFLD) 在2型糖尿病 (T2DM) 患者中显著增加内皮功能障碍的风险. 早期的NAFLD查和管理对于这一群体的心血管健康至关重要.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 内分泌学 在内分泌学.
背景情况:
- 非酒精性脂肪性肝病 (NAFLD) 通常与2型糖尿病 (T2DM) 共同存在.
- 这种并发症协同加速动脉样硬化发展.
- 通过流媒扩张 (FMD) 评估的内皮功能对心血管健康至关重要.
研究的目的:
- 调查T2DM患者中NAFLD和内皮功能障碍之间的关联.
- 为了比较T2DM患者有和没有NAFLD的口炎水平.
- 为了确定在这个群体中导致口和口病的因素.
主要方法:
- 一项涉及147名T2DM患者的横截面研究.
- 基于受控衰减参数 (CAP) 评分>302 dB/m的NAFLD诊断.
- 脑内皮功能障碍定义为手臂动脉口腔疾病 (FMD) ≤0.7%;使用回归分析.
主要成果:
- 患有NAFLD的患者表现出较高的口病发病率 (77.8%对58.7%,P=0.01).
- 多变量分析确定NAFLD (OR=2.581) 和高血压 (HTN) (OR=3.114) 是受损口病的危险因素.
- 女性性别与受损口病风险降低相关 (OR=0.371).
结论:
- 在T2DM患者中,NAFLD是内皮功能障碍的显著独立预测因子.
- 与NAFLD相关的内皮功能障碍的风险与高血压的风险相当.
- 建议对T2DM患者进行NAFLD的常规查和管理,以减轻心血管风险.
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