在剖腹产期间用于脊髓麻醉的普通罗皮瓦卡因的辅助剂:使用向上下序列分配方法确定ED50的前性,双盲,随机试验
Xiaofei Mo1, Fa Huang1, Xiaoying Wu1
1Department of Anesthesiology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
BMC anesthesiology
|September 25, 2023
概括
这项研究确定了剖腹产剖腹产时的内垂体德克斯梅德托米丁的有效剂量. 中位有效剂量 (ED50) 约为6μg与8毫克罗皮瓦卡因和3μg与10毫克罗皮瓦卡因.
科学领域:
- 麻醉学 麻醉学
- 产科麻醉 产科麻醉 产科麻醉
- 药理学 药理学是指药理学的学科.
背景情况:
- 内垂体德克斯米德提米丁可以提高脊柱麻醉的质量,并减少局部麻醉的需求.
- 在剖腹产中,内式德克斯梅德托米丁与普通罗皮瓦卡因的最佳剂量尚未确定.
研究的目的:
- 确定内式德克斯梅德托米丁的有效剂量中位数 (ED50).
- 评估其作为普通罗皮瓦卡因辅助剂在剖腹产期间用于脊髓麻醉的使用.
主要方法:
- 经过剖腹产的60名分娩妇女被随机分为两组,接受8毫克或10毫克普通罗皮瓦卡因.
- 一种上下序列方法被用来确定ED50的内性德克斯梅德托米丁,从5μg开始.
- 有效性被定义为在没有额外麻醉的情况下在10分钟内实现T6感觉阻断.
主要成果:
- 甲状腺内用德克斯梅德托米丁的ED50为5.9μg (95% CI,4.9-7.4μg) 与8毫克罗皮瓦卡因和3.1μg (95% CI,0.1-4.8μg) 与10毫克罗皮瓦卡因.
- 血液动力学稳定性,副作用,患者满意度和新生儿结局在各组之间是可比的.
结论:
- 当与8毫克普通罗皮瓦卡因相结合时,直肠内德克斯梅德托米丁的ED50大约为6微克.
- 在剖腹产脊柱麻醉中,ED50在与10毫克普通罗皮瓦卡因结合时约为3μg.
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