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In vivo Optogenetic Stimulation of the Rodent Central Nervous System
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在vivo中光学可编程的生活微路由器.

Xiaoshuai Liu1, Huaying Wu1, Shuai Wu1

  • 1Guangdong Provincial Key Laboratory of Nanophotonic Manipulation, Institute of Nanophotonics, Jinan University, Guangzhou, 511443, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|September 26, 2023
PubMed
概括
此摘要是机器生成的。

研究人员使用红细胞 (RBC) 和光学 tweezers 开发了一个生物相容的微路由器. 这种活生生的微机器人可以精确地引导各种目标,包括细胞和纳米药物,用于医疗应用.

关键词:
药物输送是药物输送的过程.纳米治疗药物 纳米治疗药物光学子,一个光学子.可编程的医疗微机器红细胞是血液中的红细胞.

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科学领域:

  • 生物医学工程 生物医学工程
  • 微型机器人技术就是微型机器人.
  • 生物相容性材料 生物相容性材料

背景情况:

  • 可编程医疗微机 (PMM) 为复杂的任务提供了高的可重配置性,但由于外部组件而面临生物相容性挑战.
  • 开发生物相容的微机器人对于体内应用,如向药物输送和细胞操纵至关重要.

研究的目的:

  • 报告一种新的生物微路由系统,用于精确的生物目标路由.
  • 克服传统外源PMM的生物相容性限制.

主要方法:

  • 用可编程扫描光学笔和光流体策略集成内源红细胞 (红细胞).
  • 利用光学力场景来控制RBC旋转,并为水力动力学力产生执行流.
  • 实现一个三功能系统:动态输入,内部处理和可选择路由的受控输出.

主要成果:

  • 证明了各种生物点的选择性路由,包括血细胞和纳米药物.
  • 成功将血小板和白细胞运送到受损血管,以进行静血和杂物清除.
  • 实现了纳米药物的精确,大量运输,以提供有针对性的输送.

结论:

  • 开发的RBC微路由器为先进的微机器人应用提供了一个生物兼容的平台.
  • 潜在的应用包括细胞分离,向药物输送和免疫治疗.
  • 这种方法为微机器人中生物组件的有机集成铺平了道路.