针对儿科瘤的瘤治疗性病毒疗法
Evan G Gross1, Mohammad A Hamo1, Dagoberto Estevez-Ordonez2
1Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Expert opinion on biological therapy
|September 26, 2023
概括
瘤溶解性病毒疗法 (OVT) 是对儿科癌症传统治疗的更安全替代方案. 虽然结果各不相同,但OVT可能成为未来儿科癌症护理的关键组成部分.
科学领域:
- 在瘤学瘤学.
- 病毒学 病毒学
- 儿科医学 儿科医学
背景情况:
- 儿科恶性瘤通常在当前的治疗方法下表现不佳.
- 标准护理 (手术,化疗,辐射) 可以导致显著的长期副作用.
- 瘤性病毒疗法 (OVT) 为儿童提供了潜在的新治疗途径.
研究的目的:
- 审查儿科癌症临床试验中使用的病毒类型.
- 讨论OVT的机制,临床前和临床发现.
- 评估OVT在儿科瘤学中的潜在作用.
主要方法:
- 在儿科瘤试验中对七种病毒类型 (腺病毒,简单疹病毒,疫苗,reovirus,脊髓灰质炎病毒,麻疹病毒,塞内卡病毒A) 的文献综述.
- 对瘤特异性复制和细胞毒性机制的分析.
- 主要临床前和临床研究发现的总结.
主要成果:
- 与化疗和放射治疗相比,OVT显示了有利的安全性.
- OVT的抗瘤作用是可变的,取决于瘤类型和病毒病原体.
- 在过去的十年里,OVT临床使用的进展是相当大的.
结论:
- 在儿童癌症患者中,OVT具有有前途的安全性.
- 对于广泛采用OVT仍然存在挑战.
- 预计OVT将在未来在治疗儿科固体瘤方面发挥重要作用,补充标准疗法.
相关概念视频
Cancer Therapies
7.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.7K
Tumor Immunotherapy
551
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
551
Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K
Treatment Resistant Cancers
3.3K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.3K
Cancer Vaccines
396
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
396
Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K


