血管内皮生长因子A血清水平和一般性牙周炎患者中常见的多态基因
Albertas Kriauciunas1, Gediminas Zekonis1, Greta Gedvilaite2,3
1Department of Prosthodontics, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Acta odontologica Scandinavica
|September 26, 2023
概括
血管内皮生长因子A (VEGFA) 基因变异,特别是rs3025033 GG基因型和A-A-G-A单体型,可以预防牙周炎. 然而,一种罕见的VEGFA亚型可能会增加牙周炎的风险.
科学领域:
- 遗传学 是一个遗传学.
- 牙周病学 牙周病学
- 分子生物学分子生物学
背景情况:
- 牙周炎是一种普遍的炎症性疾病,影响牙和支骨.
- 血管内皮生长因子A (VEGFA) 在血管生成和炎症中起作用,可能影响牙周炎的发病.
研究的目的:
- 调查VEGFA血清水平,特定的VEGFA单核酸多形态 (SNP) 和牙周炎之间的关联.
- 分析这些关联与性别的关系.
主要方法:
- 在261名牙周炎患者和441名对照患者中使用实时PCR进行VEGFASNP (rs1570360,rs699947,rs3025033,rs2146323) 的基因型鉴定.
- 在80名参与者的子集中测量了血清VEGFA水平.
- 对所研究的VEGFA SNP进行的哈普类型分析.
主要成果:
- 与对照组 (5.7%) 相比,rs3025033 GG基因型在牙周炎患者 (1.6%) 中的频率较低 (p=0.008).
- 在牙周炎患者和对照人群之间没有观察到VEGFA血清水平的显著差异.
- 维格法SNP的A-A-G-A类型与牙周炎风险降低有关 (OR=0.42),而罕见的类型增加了风险 (OR=4.08).
结论:
- rs3025033 GG基因型和VEGFA的A-A-G-A亚型可能会对牙周炎产生保护作用.
- 一种不太常见的VEGFA杂型似乎与患牙周炎的风险增加有关.
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