基于MRI的氧气全器官代谢率的量化
Rajiv S Deshpande1, Michael C Langham1, Katalin Susztak2,3
1Laboratory for Structural Physiologic and Functional Imaging, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
NMR in biomedicine
|September 26, 2023
概括
一种新的MRI技术,K-MOTIVE,非侵入性地测量脏氧气利用率 (rMRO2). 这种方法准确量化脏血流和静脉氧和度,为脏功能和疾病提供了有前途的生物标志物.
科学领域:
- 医疗成像医学成像
- 腎臟病學 (nephrology) 是一種醫學專業.
- 身体生理学 身体生理学
背景情况:
- 与糖尿病相关的缺氧有助于慢性病.
- 全器官氧代谢率 (rMRO2) 是一个潜在的功能生物标志物.
- 目前的方法缺乏绝对生理单位的rMRO2的非侵入性量化.
研究的目的:
- 介绍和评估K-MOTIVEMRI序列用于非侵入性rMRO2测量.
- 评估K-MOTIVE在量化脏血流 (RBF) 和静脉氧和 (SvO2) 的性能.
- 确定K-MOTIVE用于rMRO2评估的可重现性和灵敏性.
主要方法:
- 开发了K-MOTIVEMRI序列,结合相位对比和T2准备的bSSFP.
- 测量RBF和SvO2在一次22秒的喘息中.
- 使用Fick原理在15名健康受试者中计算rMRO2在3T.
主要成果:
- K-MOTIVE精确测量了T2,SvO2 (92%±6%),RBF (400±110毫升/分钟) 和rMRO2 (114±117 (μmol O2/分钟) / 100g) 的时间.
- 测量T2和RBF的可复制性显示变化系数<10%.
- 一个高蛋白饮食挑战增加了rMRO2,由血清生物标志物证实.
结论:
- K-MOTIVE 允许可行和可重复的全器官rMRO2.2 的非侵入性量化.
- 这种MRI技术测量了rMRO2计算的基本参数 (RBF,SVO2).
- 通过K-MOTIVE测量的rMRO2是对脏健康的潜在有价值的生理生物标志物.
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