在一个大型风湿病学实践网络中,COVID-19疫苗接种,犹和爆发
Emily E Holladay1, Amy S Mudano2, Fenglong Xie2
1University of Alabama at Birmingham, Birmingham.
Arthritis care & research
|September 26, 2023
概括
接种COVID-19疫苗的比例很高,但患有自身免疫和炎症性类风湿性疾病 (AIIRD) 的患者表现出更多的犹. 需要进行干预,因为AIIRD患者接种疫苗的可能性较低.
科学领域:
- 类风湿病学 类风湿病学
- 传染病流行病学 传染病流行病学
- 公共卫生 公共卫生
背景情况:
- 了解COVID-19疫苗接种和犹是至关重要的,特别是在自身免疫和炎症性类风湿性疾病 (AIIRDs) 的患者群体中.
- 之前的研究还没有完全阐明疫苗犹因素或自我报告的疾病爆发在这个特定的人群在一个大型的风湿病学网络.
研究的目的:
- 为了确定COVID-19疫苗和助推剂吸收率.
- 找出患者,特别是那些患有AIIRDs的疫苗和助推剂犹的原因.
- 评估AIIRD状态和疫苗接种后自我报告的疾病爆发之间的关联.
主要方法:
- 从2021年12月到2022年12月,在108个类风湿病诊所进行了基于平板电脑的调查.
- 使用描述性统计和多变量后勤回归来比较疫苗接种状态,犹和AIIRD患者和无AIIRD患者之间的爆发.
- 调整的赔率比率 (aORs) 被计算出来,以检查关联.
主要成果:
- 在61158名患者中,89%的患者至少接种了一剂疫苗,其中68%接种了强剂.
- 与没有AIIRDs的患者相比,患有AIIRDs的患者表现出更高的疫苗 (14%vs10%) 和增强剂犹 (21%vs16%).
- 安全问题和副作用是疫苗犹的主要原因,而缺乏医生建议导致了增剂犹. 患有AIIRD的患者接种疫苗的可能性降低了32%.
- 在患有AIIRD (aOR 0.99) 的患者中,没有观察到自我报告爆发的可能性增加.
结论:
- 尽管总体接种疫苗的比例很高,但很大一部分患者,特别是那些患有AIIRD的患者,表达了犹.
- 一部分犹不决的人最终接受了疫苗接种,这表明有针对性的干预措施的潜在有效性.
- 未来的干预措施应该为患有AIIRD的患者量身定制,以改善疫苗和助推剂的吸收.
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