14天的诺普拉赞基比斯穆特四重疗法治疗先前未经治疗的Helicobacter pylori感染患者:一项回顾性比较研究
Feifei Lu1,2, Wentao Xu2, Xiaoye Shi2
1College of Medicine and Biological Information Engineering, Northeastern University, Shenyang, Liaoning, 110167, People's Republic of China.
International journal of general medicine
|September 26, 2023
概括
这项研究发现,14天的基于诺普拉桑的双四次疗法 (BQT) 与基于潘托普拉的BQT一样有效和安全,用于在未经治疗的患者中根除Helicobacter pylori.
科学领域:
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 有限的临床证据表明,14天的基于诺普拉桑的木四倍疗法 (BQT) 在 Helicobacter pylori (H. pylori) 根除中.
- 杆菌感染仍然是一个重大的全球健康问题,需要有效的治疗策略.
研究的目的:
- 为了评估14天的诺普拉赞基BQT治疗方案的临床疗效和安全性,与基于潘托普拉的BQT治疗方案相比,用于根除H. pylori.
- 提供证据证明诺普拉赞在H. pylori治疗方案中的使用.
主要方法:
- 对65名先前未接受过治疗的H.pylori感染患者进行了回顾性分析.
- 患者接受了14天的基于诺普拉桑的BQT (VBCA,n=17) 或基于潘托普拉的BQT (PBCA,n=48) 方案.
- 两组之间的H. pylori根除率和不良事件的比较.
主要成果:
- 基于诺普拉桑 (88.2%) 和基于潘托普拉 (91.7%) 的组之间的H. pylori根除率没有显著差异 (p=1,000).
- 在VBCA (52.9%) 和PBCA (64.6%) 组 (p=0.397) 中,不良事件发生率也相似.
结论:
- 诺普拉桑在14天的BQT中显示出与潘托普拉相似的疗效和安全性,用于在未经治疗的患者中消除H. pylori.
- 诺普拉桑在BQT治疗方案中代表了一种可行的替代方案,用于治疗H.pylori感染.
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