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为治疗COVID-19引起的嗅觉功能障碍而建立的恒星性结块:一个潜在的试点研究

Andrew M Peterson¹, Brevin J Miller¹, Dorina Kallogjeri¹

¹Clinical Outcomes Research Office, Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine in St Louis, St Louis, Missouri, USA.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

|September 26, 2023

概括

星状质块 (SGBs) 显示出治疗持续的COVID-19诱导的嗅觉功能障碍 (OD) 的前景. 这项试点研究发现,SGB是安全的,55%的参与者表现出更好的嗅觉识别,35%的人报告了更好的生活质量.

科学领域:

神经学神经学
耳鼻喉科耳鼻喉科耳鼻喉科
传染性疾病传染性疾病

背景情况:

持续的嗅觉功能障碍 (OD) 是COVID-19的常见后果.
目前用于COVID-19后OD的治疗方法的疗效有限.
星状质块 (SGBs) 是一种干预性治疗方式,在神经和炎症疾病中具有潜在的应用.

研究的目的:

评估SGBs的安全性和可行性,用于治疗COVID-19引起的持续性OD.
为了确定未来随机临床试验的效果大小.

主要方法:

成年参与者有至少12个月的COVID-19和OD病史的潜在病例系列.
双边SGBs被管理,随后是1个月的观察期.
主要结局:临床全球印象改善量表. 二次结果:宾夕法尼亚大学气味识别测试 (UPSIT) 和嗅觉功能障碍结果评分 (ODOR).

主要成果:

招募了20名参与者 (平均年龄46岁,平均OD持续时间21个月).
在SGB后1个月,50%的人报告了OD的主观改善,55%的人显示UPSIT得分有临床意义的改善,35%的人改善了嗅觉特异性生活质量 (ODOR).
在UPSIT得分中,中位数的改善 (6分) 超过了临床上重要的最小差异.

结论:

顺序性SGB似乎是COVID-19相关的OD的安全治疗方法.
在主观嗅觉,气味识别和生活质量方面观察到适度的改善.
建议进行安慰剂对照试验,以确认SGBs对这种疾病的疗效.

关键词:

在 COVID-19 疫情中,厌食症是一种厌食症.缺血症缺血症是一种缺血症.嗅觉嗅觉是一种嗅觉.星状团的星状团

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