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适合和小的怀孕年龄和早产婴儿的男性满期新生儿的迷你青春期:来自单一中心的数据
Alessandra Boncompagni1, Elisa Pietrella2, Erica Passini1
1University of Modena and Reggio Emilia, Department of Medical and Surgical Sciences of Mothers, Children and Adults, Neonatal Intensive Care Unit, Modena, Italy
Journal of clinical research in pediatric endocrinology
|September 26, 2023
概括
产后的下垂体-垂体-淋巴结核 (HPG) 轴激活,或迷你青春期,在早产婴儿中显示出不同的模式,尿液淋巴结核和丸激素的水平较高. 这种早期的HPG轴功能可能对发育至关重要.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 新生儿生理学 新生儿生理学
- 生殖医学 生殖医学
背景情况:
- 被称为"迷你青春期"的下丘脑 - 垂体 - 淋巴腺 (HPG) 轴的产后激活尚未完全理解,特别是关于基于妊娠年龄 (GA) 和出生体重 (BW) 的变化.
- 关于小青春期与性别,GA和BW相关的功能意义的纵向数据有限.
研究的目的:
- 在男性新生儿中纵向量化尿囊刺激激素 (uFSH),化激素 (uLH) 和 (uTs).
- 为了比较HPG轴激活模式,适合妊娠年龄的满期新生儿 (FT AGA),适合妊娠年龄的满期新生儿 (FT SGA) 和早产 (PT) 新生儿.
- 为了将尿道激素水平与外泌学参数,线性生长和外部生殖器官发育相关联.
主要方法:
- 一个单中心的纵向研究,涉及46名男性新生儿.
- 分为三组分层:FT AGA (n=23),FT SGA (n=11) 和PT (≤33周GA,n=12).这些组分为三组:FT AGA (n=23),FT SGA (n=11) 和PT (≤33周GA,n=12).
- 测量尿道激素 (uFSH, uLH, uTs) 和与生长和生殖器官参数的相关性.
主要成果:
- 预产 (PT) 男孩表现出脉动性尿性淋巴激素 (uGns) 与升高的Luh和增加的UTs,以及早期的丸下降.
- 完全适合妊娠年龄 (FT AGA) 的男孩在预产后的第一个12个月 (PTA) 中表现出优异的线性生长.
- 与FT AGA相比,PT婴儿在PTA3个月前的GGns较高,在前90天的Luh显著更高,UT升高. 阴茎生长与UT总体有显著的相关性.
结论:
- 产后的HPG轴激活 (迷你青春期) 在预产和早产婴儿之间有所不同,这表明评估HPG轴功能的早期窗口.
- 怀孕年龄和出生体重显著影响小青春期的模式和早期发育.
- 需要进一步的长期后续研究来阐明GA和BW对HPG轴功能的影响.
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