影响骨质平衡的药物对短期和长期植入物衰竭的影响
Junho Jung1, Jae-In Ryu2, Gyu-Jo Shim1
1Department of Oral & Maxillofacial Surgery, College of Dentistry, Kyung Hee University, Kyung Hee University Medical Center, Seoul, Korea.
Clinical oral implants research
|September 26, 2023
概括
证据将骨稳定剂与牙植入物失败联系在一起是有限的. 虽然一些药物可能会带来风险,但需要进一步的研究来证实它们对植入物存活和骨质整合的影响.
科学领域:
- 牙科植入物学 牙科植入物学
- 骨生物学 骨生物学 骨生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 影响骨质平衡的药物越来越多地用于各种医疗条件.
- 了解它们对牙植入成功的潜在影响对于患者护理至关重要.
- 现有的文献提出了关于这些药物和植入物结果的相互矛盾的证据.
研究的目的:
- 系统地审查有关骨质稳定剂和牙植入物失败之间的关系的现有证据.
- 确定特定的药物及其与植入物治疗相关的潜在风险.
主要方法:
- 进行了全面的电子数据库搜索,查找关键的骨修饰剂 (双酸盐,德诺苏马布,甲铁酸盐,皮质类固醇,罗莫苏马布,苏尼尼布,贝瓦西苏马布).
- 搜索内容包括PubMed,MEDLINE,EMBASE,科克伦图书馆和科学网.
- 为了补充数字发现,对最新文献进行手动搜索.
主要成果:
- 双酸盐:通常被认为是安全的,但高剂量的静脉注射治疗可能会增加植入物失败的风险.
- 植入物周围的与药物相关的骨 (MRONJ) 是一个令人担忧的问题,导致晚期失败.
- 代诺苏马布,甲铁和皮质类固醇:有证据表明它们对骨代谢有有害影响,但它们在植入物存活中的直接作用仍然是不确定的.
结论:
- 目前还没有足够的证据直接将骨质稳定剂与植入物失败联系起来.
- 一些研究表明负面结果,在接受抗吸收疗法的患者中观察到与植入物相关的封存.
- 临床医生必须仔细考虑与药物相关的潜在风险,并在植入物治疗期间实施预防措施.
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