评估与宿主相关的微生物组中的共同多样化
Andrew H Moeller1, Jon G Sanders1, Daniel D Sprockett1
1Department of Ecology and Evolutionary Biology, Cornell University, Ithaca, New York, USA.
Journal of evolutionary biology
|September 26, 2023
概括
这项研究引入了新的方法来检测复杂的宿主-微生物关系中的共同多样化. 通过分析整个微生物群落,研究人员现在可以在多样化的宿主相关微生物群中识别古代的共生血统.
科学领域:
- 进化生物学 进化生物学
- 微生物生态学 微生物生态学
- 基因组学就是基因组学.
背景情况:
- 宿主-微生物相互作用可以导致并行进化的多样化 (共同多样化).
- 以前的共同多样化测试仅限于简单的,二进制的主机-共生系统.
- 复杂的宿主相关微生物群对评估共同多样化提出了挑战.
研究的目的:
- 审查复杂微生物群中共同多样化的证据.
- 为多方共生概述一个假设测试方法.
- 倡导微生物群全方位扫描,以确定共同多样化的共生生物系.
主要方法:
- 将共同多样化测试扩展到整个微生物基因组 (例如,元基因组组合基因组,安普利康序列变异).
- 使用微生物群全方位扫描来识别宿主群体内的共同多样化的共生生物.
- 采用多层次的顺序测试,以解释族系学非独立性和多重比较.
主要成果:
- 开发和讨论了微生物群广泛的共同多样化分析工具.
- 展示了如何在复杂的微生物群落中识别共同多样化的共生生物.
- 共生群的相对年龄可以证实共同多样化的发现.
结论:
- 共同多样化测试可以成功地扩展到复杂的微生物群.
- 微生物群全方位扫描提供了一种强大的方法来发现古代的共生血统.
- 这种框架使得在与宿主相关的共生体中对分子进化和血统周转的质疑成为可能.
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