与轻度认知衰退的中风幸存者的混合运动-认知训练相关的神经可塑性变化:随机对照试验
Ting-Ting Yeh1, Ku-Chou Chang2,3,4, Jiun-Jie Wang5,6,7
1Master Degree Program in Health and Long-term Care Industry, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Neurorehabilitation and neural repair
|September 26, 2023
概括
在中风幸存者中,连续的运动-认知训练比双重任务训练更加强大脑连接. 这两种方法都显示出明显的神经可塑性变化,但并没有显著改善认知功能.
科学领域:
- 神经科学是一个神经科学.
- 康复医学 康复医学 康复医学
- 认知科学 认知科学
背景情况:
- 运动和认知训练在中风后促进神经可塑性和认知功能.
- 混合运动-认知训练对脑皮质活动和中风后认知功能的影响需要进一步研究.
研究的目的:
- 调查顺序性 (SEQ) 和双任务 (DUAL) 混合运动-认知训练对神经可塑性变化和轻度认知衰退中风幸存者的行为结果的影响.
主要方法:
- 一个单盲随机对照试验,涉及3组:SEQ,DUAL和对照 (CON).
- 参与者接受了12周的培训 (60分钟/天,3天/周).
- 主要结果:通过fMRI休息状态功能连接 (FC);次要结果:认知和身体功能.
主要成果:
- 与DUAL和CON组相比,SEQ组在左叶,后带状回环和右叶之间显示出增加的静止状态FC.
- 在DUAL组,左叶的FC增加.
- 在这三个组中,没有观察到行为结果的显著差异.
结论:
- 这项研究揭示了在中风幸存者的连续和双重任务运动认知训练方法背后的独特的神经可塑性机制.
- fMRI测量表明,在不同的训练范式之后,认知恢复的神经机制.
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